Sublingual

asenapine

Saphris

Safety Verdicts

Crush

✕Do not

SAPHRIS sublingual tablets should not be split, crushed, chewed, or swallowed [see Clinical Pharmacology ( 12.

FDA label

Split

✕Do not

SAPHRIS sublingual tablets should not be split, crushed, chewed, or swallowed [see Clinical Pharmacology ( 12.

FDA label

Open Capsule

—N/A

Capsule-opening is not addressed for this product (tablet form, or no guidance given).

Textbook

Formulation Mechanism

Textbook

Sublingual tablets are made to dissolve under the tongue and absorb directly through the lining of the mouth. Crushing or swallowing them defeats this route and can change how much drug reaches the bloodstream.

Last reviewed: 2026-06-03

This tool shows mechanism, verdict, and alternative data only — not patient-specific advice. A “can crush” result is a general guide, not a guarantee for your exact product: the same ingredient can differ by brand, manufacturer, and formulation. Data comes from U.S. drug labels and covers a limited set of medicines — if a drug isn’t listed, that is not a green light to crush it. Always confirm with your pharmacist or physician before altering how a medication is administered.